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Month

September 2018

New cancer vaccine shows early promise for patients with HER2-positive cancers

Treatment with a HER2-targeted therapeutic cancer vaccine provided clinical benefit to several patients with metastatic HER2-positive cancers who had not previously been treated with a HER2-targeted therapeutic, according to data from a phase I clinical trial presented at the Fourth… Continue Reading →

Bacterial therapy tolerable, shows early promise in patients with advanced solid tumors

A phase I clinical trial investigating the use of bacterial Clostridium novyi-NT spores as an injectable monotherapy had manageable toxicities and showed early clinical efficacy in patients with treatment-refractory solid tumor malignancies, according to data presented at the Fourth CRI-CIMT-EATI-AACR… Continue Reading →

Scientists use AI to develop better predictions of why children struggle at school

Scientists using machine learning — a type of artificial intelligence — with data from hundreds of children who struggle at school, identified clusters of learning difficulties which did not match the previous diagnosis the children had been given. The researchers… Continue Reading →

Unveiling the mechanism protecting replicated DNA from degradation

Researchers from Tokyo Metropolitan University and the FIRC Institute of Molecular Oncology (IFOM) in Italy have succeeded in depleting AND-1, a key protein for DNA replication, by using a recently developed conditional protein degradation system. Consequently, they were able to… Continue Reading →

US Food Brands Petition EPA to Ban Pre-Harvest Glyphosate Spraying

The Environmental Working Group, joined by food and nutrition companies including MegaFood, Ben & Jerry’s, Stonyfield Farm, MOM’s Organic Market, Nature’s Path, One Degree Organic Foods, National Co+op Grocers and Happy Family Organics, petitioned the Environmental Protection Agency on Thursday… Continue Reading →

Foods With the Most Pesticides, How to Avoid Them

Consumer Reports found organic foods are, on average, 47 percent more expensive than non-organic. For people wanting to avoid exposure to pesticides in produce and watch what they spend, there are some fruits and veggies that are more important to… Continue Reading →

Oregon County Pesticide Ban Model for Fight Against Farm Chemicals

A grassroots effort in a seaside Oregon county last year could serve as an example for how other communities can beat large corporate interests. Last year, Lincoln County voters banned the aerial application of pesticides, despite opposition backing from companies… Continue Reading →

Monsanto's Role in Roundup Safety Study Is Corrected by Journal

Bayer AG’s defense of Roundup weed killer may take a hit after an academic journal said Monsanto Co. didn’t fully disclose its involvement in published research finding the herbicide safe. A correction issued by Critical Reviews in Toxicology, a journal… Continue Reading →

First-born children more likely to learn about sex from parents

Birth order may play a significant role in how children learn about sex, especially for boys, according to a new study published in the journal Sex Education. Researchers found that first-born children were more likely to report parental involvement in… Continue Reading →

Quantum mechanics work lets oil industry know promise of recovery experiments

With their current approach, energy companies can extract about 35 percent of the oil in each well. Every 1 percent above that, compounded across thousands of wells, can mean billions of dollars in additional revenue for the companies and supply… Continue Reading →

Acne stigma linked to lower overall quality of life, Irish study finds

Many people with acne are negatively impacted by perceived social stigma around the skin condition, a new study from University of Limerick (UL), Ireland, has found. A survey of 271 acne sufferers has revealed that their own negative perceptions of… Continue Reading →

Value in unusual type of plant material

An ideal biorefinery would turn renewable crops into a variety of fuels and products with little waste. A significant challenge in realizing this vision is what to do with lignin, a fibrous and difficult-to-break-down material in the cell walls of… Continue Reading →

Hidden health problems can appear up to two years after elective hip surgeries

Up to two years following elective, arthroscopic hip surgery, a substantial proportion of patients reported troubling new health issues ranging from sleep problems, to arthritis to cardiovascular disease. While such problems can be transient and diminish as full mobility returns,… Continue Reading →

Bacterial protein mimics DNA to sabotage cells’ defenses

Infections with Salmonella bacteria, often caused by eating or handling undercooked meat or eggs, affect about 100 million people a year worldwide. The suffering the infection causes — abdominal cramps, fever and diarrhea — is the result of an extremely… Continue Reading →

Experimental Martian dirt: $20 a kilogram, plus shipping

The University of Central Florida is selling Martian dirt, $20 a kilogram plus shipping. This is not fake news. A team of UCF astrophysicists has developed a scientifically based, standardized method for creating Martian and asteroid soil known as simulants…. Continue Reading →

Factors linked to mortality after traumatic brain injury identified

Model system researchers have examined the factors associated with mortality among individuals aged 16 years and older who were more than one year post- traumatic brain injury (TBI). Their article: O'Neil-Pirozzi- T, Ketchum JM, Hammond FM, Phillipus A, Weber E,… Continue Reading →

Corn and Ethanol Partner to Educate Anglers

For the second year, the Renewable Fuels Association has been co-title sponsor, with Bass Pro Shops, of the Crappie Masters Tournament Trail, with the 2018 National Championship held this week in Clinton, Missouri on Truman Lake. The corn growers were… Continue Reading →

Did key building blocks for life come from deep space?

All living beings need cells and energy to replicate. Without these fundamental building blocks, living organisms on Earth would not be able to reproduce and would simply not exist. Little was known about a key element in the building blocks,… Continue Reading →

New way to control meandering electrons and generate extreme-ultraviolet emissions

A team at the Center for Relativistic Laser Science, within the Institute for Basic Science (IBS), has found a completely new way to generate extreme-ultraviolet emissions, that is light having a wavelength of 10 to 120 nanometers. Published in Nature… Continue Reading →

How Sacred Ibis mummies provided the first test of evolution

A debate over mummified birds brought to France after Napoleon's conquest of Egypt played a central role in delaying acceptance of evolutionary theory; an episode in the history of biology revealed in an Essay published September 27 in the open-access… Continue Reading →

Now is the time to answer questions about climate engineering disease impacts

Radical solutions to climate change might save lives, but a commentary in the October 2018 issue of the journal Nature Climate Change calls for caution because geoengineering still lacks a "clean bill of health." With global fossil-fuel emissions reaching an… Continue Reading →

In dangerous fungal family’s befriending of plants, a story of loss

If Lewis Carroll had described in detail the mushroom Alice nibbles in Wonderland to shrink and grow to her rightful size, he might have noted a scarlet cap topped with white warts: the fly amanita. This brilliant, distinctive toadstool is… Continue Reading →

Genetic basis for how harmful algae blooms become toxic

Scientists have uncovered the genetic basis for the production of domoic acid, a potent neurotoxin produced by certain harmful algae blooms. In a new study appearing in this week's issue of the journal Science, researchers identified a cluster of genes… Continue Reading →

The cart before the horse: A new model of cause and effect

Natural little scientists, human babies love letting go of things and watching them fall. Baby's first experiment teaches them about more than the force of gravity. It establishes the concept of causality — the relationship between cause and effect that… Continue Reading →

Fewer biofuels, more green space: Climate action researcher calls for urgent shift

Growing and harvesting bioenergy crops — corn for ethanol or trees to fuel power plants, for example — is a poor use of land, which is a precious resource in the fight against climate change, says a University of Michigan… Continue Reading →

New, highly stable catalyst may help turn water into fuel

Breaking the bonds between oxygen and hydrogen in water could be a key to the creation of hydrogen in a sustainable manner, but finding an economically viable technique for this has proved difficult. Researchers report a new hydrogen-generating catalyst that… Continue Reading →

Steelhead life cycle linked to environment, pink salmon abundance

A Simon Fraser University study has found that steelhead trout have a remarkable life-cycle variation that responds to changes in temperature and numbers of other species of salmon. They may go to the ocean when they are only a year… Continue Reading →

Cancer hijacks the microbiome to glut itself on glucose

Cancer needs energy to drive its out-of-control growth. It gets energy in the form of glucose, in fact consuming so much glucose that one method for imaging cancer simply looks for areas of extreme glucose consumption — where there is… Continue Reading →

Building a flu factory from host cell components

Perhaps inspired by the annual 3 to 5 million cases of severe influenza worldwide, the Guinness World Record organization is advertising for individuals or organizations to attempt a record for the most people getting a flu awareness lesson at once…. Continue Reading →

Researchers challenge our assumptions on the effects of planetary rotation

Earth's rotation causes the Coriolis effect, which deflects massive air and water flows toward the right in the Northern Hemisphere and toward the left in the Southern Hemisphere. This phenomenon greatly impacts global wind patterns and ocean currents, and is… Continue Reading →

Zimfo Bytes 9/28

The Feeding America Board of Directors announced, effective October 1, 2018, Claire Babineaux-Fontenot will become the organization’s new CEO. Calyxt, Inc. and Cellectis S.A. announced the appointment of James A. Blome, former President and CEO of Bayer CropScience LP (North… Continue Reading →

Continuing Resolution Passes House, Agriculture “Minibus” Stuck

Tractor stuck in the mud. Photo credit: Jess Johnson Earlier this week, the House passed a Continuing Resolution (CR) for spending bills that have not yet been passed, which would extend government funding levels from fiscal year (FY) 2018 through… Continue Reading →

Teens who’ve tried marijuana have used it in more than one form

Most teens who've tried marijuana have used the drug in more than one form, including cannabis products that are smoked, eaten or vaped, new USC research shows. The study, published Friday in JAMA Network Open, raises concerns about adolescent health… Continue Reading →

Perovskite solar cells leap toward commercialization

Solar energy has long been considered the most sustainable option for replacing our dependence on fossil fuels, but technologies for converting solar energy into electricity must be both efficient and inexpensive. Scientists from the Energy Materials and Surface Sciences Unit… Continue Reading →

New insights into the structure of a killer protein

Researchers at Ruhr-Universität Bochum and the University of Tübingen have gained new insights into the structure of the killer protein Bax. The protein induces programmed cell death, the method by which the body disposes of cells that are no longer… Continue Reading →

New approach offers high-resolution seismic monitoring of the shallow subsurface

Accurate monitoring of the ground beneath our feet for signs of seismic activity to identify natural phenomena such as earthquakes, volcanic eruptions and the leakage of fluids stored deep underground remains challenging. Time-lapse 4-dimensional seismic monitoring surveys that employ an… Continue Reading →

Machine learning helps improve photonic applications

Nanostructures can increase the sensitivity of optical sensors enormously — provided that the geometry meets certain conditions and matches the wavelength of the incident light. This is because the electromagnetic field of light can be greatly amplified or reduced by… Continue Reading →

A 3-D-printed phantom head

Phantoms are not just ghostly figures of our imagination, they are also numerical or physical models that represent human characteristics and provide an inexpensive way to test electromagnetic applications. Sossena Wood, a bioengineering PhD candidate at the University of Pittsburgh,… Continue Reading →

Green mango peel: A slick solution for oil-contaminated soils

Nanoparticles derived from green mango peel could be the key to remediating oil sludge in contaminated soil according to new research from the University of South Australia. For the petroleum industry remediating oil sludge is a costly and an ongoing… Continue Reading →

Olympia Auset is Tackling Systemic Racism, One Vegetable at a Time

Olympia Auset’s mission is simple: use food to help eradicate racial inequality. SÜPRMARKT, a pop-up grocery store offering low-cost, organic foods, is her first step. The store’ colorful tables and boxes of bananas, coconuts, peppers, and greens spring up in… Continue Reading →

Improved In vivo imaging of atherosclerotic plaque development

Atherosclerosis, involving the buildup of plaque in the arteries and an associated reduction in the flow of blood, is a major feature of cardiovascular diseases. Although advances have been made in characterizing how this buildup occurs and ways to reduce… Continue Reading →

Observing the development of a deep-sea greenhouse gas filter

Large quantities of the greenhouse gas methane are stored in the seabed. Fortunately, only a small fraction of the methane reaches the atmosphere, where it acts as a climate-relevant gas, as it is largely degraded within the sediment. This degradation… Continue Reading →

Neglected baby beetles evolve greater self-reliance

In gardens, parks and woods across the UK, the Sexton burying beetle Nicrophorus vespilloides quietly buries dead mice and other small vertebrates to create edible nests for their young. Most parents remove the animal's hair and slash the flesh of… Continue Reading →

How some algae may survive climate change

Green algae that evolved to tolerate hostile and fluctuating conditions in salt marshes and inland salt flats are expected to survive climate change, thanks to hardy genes they stole from bacteria, according to a Rutgers-led study. These Picochlorum single-celled species… Continue Reading →

Court Stops Industrial Fish Farms in Gulf of Mexico

Yesterday, an unusual coalition of fishing and public interest groups, represented by the Center for Food Safety, won a lawsuit challenging the Department of Commerce's rules that would have permitted, for the first time, industrial finfish farms offshore in U.S…. Continue Reading →

The Death of Fabián Tomasi

Argentine farmworker and outspoken advocate against agrochemicals Fabián Tomasi passed away last week, leaving behind a defiant call to action The historic victory last month in the case of Dewayne Johnson v. Monsanto reverberated around the world. It confirmed what,… Continue Reading →

In a Warming World, Carolina CAFOs Are a Disaster for Farmers, Animals and Public Health

In the aftermath of Hurricane Florence, I've joined millions who've watched with horror as the Carolinas have been inundated with floodwaters and worried about the various hazards those waters can contain. We've seen heavy metal-laden coal ash spills, a nuclear… Continue Reading →

New invasive bryozoan arrives in Alaskan waters

Alaska has a near-pristine marine ecosystem — it has fewer invasive species in its waters than almost any other state in the U.S. But that could be changing. With help from local volunteers, biologists at the Smithsonian Environmental Research Center… Continue Reading →

Hospital privacy curtains may harbor dangerous germs

Without timely intervention, privacy curtains in hospitals can become breeding grounds for resistant bacteria, posing a threat to patient safety, according to new research published in the American Journal of Infection Control (AJIC), the journal of the Association for Professionals… Continue Reading →

Vitamin D supplements may promote weight loss in obese children

Vitamin D supplements may promote weight loss and reduce risk factors for future heart and metabolic disease in overweight and obese children, according to research presented today at the 57th Annual European Society for Paediatric Endocrinology Meeting. These findings indicate… Continue Reading →

Following the path of chemicals through the soil

Maybe the genetic test report your doctor ordered says your DNA contains many "variants of unknown significance." Currently, up to 70 percent of such reports are negative or inconclusive. But suppose at a later date a researcher discovers one of… Continue Reading →

Deaths of despair: The opioid epidemic is just part of the problem

Opioid-related deaths contributed to more than 60,000 U.S. lives lost in 2016 but absolute declines in life expectancy relative to other countries and in various measures of psychosocial well-being have been observed starting as early as 1980. Increases in despair… Continue Reading →

Hawai’i land impacted by sea level rise may be double previous estimates

By including models of dynamical physical processes such as erosion and wave run-up, a team of researchers from the University of Hawai'i at Mānoa (UH Mānoa) and the Hawai'i Department of Land and Natural Resources (DLNR) determined that land area… Continue Reading →

I Saw Florence Sending Millions of Gallons of Animal Poop Flooding Across North Carolina

I’ve been watching from the air with alarm. Though corporate farmers call them “lagoons,” I hesitate to use that word. Really, they’re cesspools: unlined open-air pits, often containing millions of gallons of hog feces and urine. North Carolina is home… Continue Reading →

'Natural' Bread Tests Positive for Glyphosate

Three non-profits have sued sandwich chain Pret A Manger for labeling certain breads and baked goods as "natural" when they tested positively for glyphosate, Beyond Pesticides announced in a press release Wednesday. The suit was filed by Richman Law Group… Continue Reading →

Breakthrough in the hunt for a vaccine against foal pneumonia

A vaccine against deadly foal pneumonia might finally be within reach, thanks to Morris Animal Foundation-funded research conducted at two major universities. The breakthrough could potentially save the lives of thousands of foals every year. "After many decades of efforts,… Continue Reading →

Polymer coating cools down buildings

With temperatures rising and heat-waves disrupting lives around the world, cooling solutions are becoming ever more essential. This is a critical issue especially in developing countries, where summer heat can be extreme and is projected to intensify. But common cooling… Continue Reading →

When neglected children become adolescents

Many migrant children separated from their parents at the U.S. border, some of them very young, have landed in shelters where they often experience stress, neglect and minimal social and cognitive stimulation. The latest findings of the long-running Bucharest Early… Continue Reading →

Vampire bats found to carry infectious bacteria at high rates

Bartonella are bacteria that cause endocarditis, a potentially life-threatening illness in humans and domestic animals. In Latin America, common vampire bats (Desmodus rotundus) are frequently infected by Bartonella, and their subsistence on blood creates a risk for bacterial transmission from… Continue Reading →

Device that integrates solar cell and battery could store electricity outside the grid

Scientists in the United States and Saudi Arabia have harnessed the abilities of both a solar cell and a battery in one device — a "solar flow battery" that soaks up sunlight and efficiently stores it as chemical energy for… Continue Reading →

Feeding ants dopamine might make them smarter foragers

In an ant colony, few tasks are as important as gathering food. But the desert heat can pose a challenge for an ant on foraging duty. Recent findings, publishing in the journal iScience on September 27, show how dopamine may… Continue Reading →

New bird flu viruses in ducks after vaccines largely prevented H7N9 in chickens

In response to bird flu pandemics starting in 2013, officials in China introduced a new vaccine for chickens in September 2017. Recent findings suggest that the vaccine largely worked but detected two new genetic variations of the H7N9 and H7N2… Continue Reading →

Ancient past of a body plan code probed

Researchers from the Stowers Institute for Medical Research have opened a window on another piece of evolutionary biology. They have found that Hox genes, which are key regulators of the way the bodies of bilaterally symmetrical animals form, also play… Continue Reading →

How Natural Killer cells regulate protective HIV antibodies

In the quest to develop a vaccine that triggers the immune system to prevent HIV infection, researchers have focused on identifying and eliciting a particular type of antibody that is capable of neutralizing the virus. These broadly neutralizing antibodies, or… Continue Reading →

Skin is a battlefield for mutations

Normal skin contains a patchwork of mutated cells, yet very few go on to eventually form cancer and scientists have now uncovered the reason why. Researchers at the Wellcome Sanger Institute and MRC Cancer Unit, University of Cambridge genetically engineered… Continue Reading →

Why a ‘cuckoo in the nest’ can go undetected

Researchers at the Universities of Exeter and Cambridge have shed light on why some species cannot tell the difference between their own offspring and those of intruders that have been slipped into their nests. It has previously been observed that… Continue Reading →

Women much less likely to ask questions in academic seminars than men

A new study reveals a stark disparity between male and female participation in a key area of academic life and offers recommendations to ensure all voices are heard. Women are two and a half times less likely to ask a… Continue Reading →

New electro-optic laser pulses 100 times faster than usual ultrafast light

Physicists at the National Institute of Standards and Technology (NIST) have used common electronics to build a laser that pulses 100 times more often than conventional ultrafast lasers. The advance could extend the benefits of ultrafast science to new applications… Continue Reading →

Sugar-powered sensor developed to detect, prevent disease

Researchers at Washington State University have developed an implantable, biofuel-powered sensor that runs on sugar and can monitor a body's biological signals to detect, prevent and diagnose diseases. A cross-disciplinary research team led by Subhanshu Gupta, assistant professor in WSU's… Continue Reading →

PCB pollution threatens to wipe out killer whales

More than forty years after the first initiatives were taken to ban the use of PCBs, the chemical pollutants remain a deadly threat to animals at the top of the food chain. A new study, just published in the journal… Continue Reading →

‘Cellular memory’ of DNA damage in oocyte quality control

Females are born with a finite number of eggs that are steadily depleted throughout their lifetime. This reserve of eggs is selected from a much larger pool of millions of precursor cells, or oocytes, that form during fetal life. So… Continue Reading →

New gene variants associated with chronic back pain

Chronic back pain is the number one cause of years lived with disability worldwide. In a new study, Pradeep Suri of the Department of Veterans Affairs in Seattle, Washington, and colleagues in the United States and Europe, in association with… Continue Reading →

Predicting US end-of-season corn yield

Crop yield predictions are a key driver of regional economy and financial markets, impacting nearly the entire agricultural supply chain. That's why economists, agricultural researchers, government agencies, and private companies are working to improve the accuracy of these predictions. The… Continue Reading →

Amazon mangroves store twice as much carbon per acre as region’s famous rainforest

Scientists have determined for the first time that Amazon's waterlogged coastal mangrove forests, which are being clear cut for cattle pastures and shrimp ponds, store significantly more carbon per acre than the region's famous rainforest. The long-term study, recently published… Continue Reading →

The hormone FGF23 is linked to structural deficits in the brain

Scientists at the Medical University of South Carolina (MUSC) have uncovered mechanisms by which high levels of a hormone called FGF23 can reduce brain health. In results published in the journal PLoS ONE on September 7th, 2018, high levels of… Continue Reading →

Large stretches of coral reefs can be rehabilitated

Even after being severely damaged by blast fishing and coral mining, coral reefs can be rehabilitated over large scales using a relatively inexpensive technique, according to a study led by the University of California, Davis, in partnership with Mars Symbioscience…. Continue Reading →

How a sleeping cancer awakens and metastasizes

Scientists at Cold Spring Harbor Laboratory (CSHL) have determined one of the ways in which cancers in remission can spring back into action. This knowledge has inspired a new treatment idea designed to prevent cancer recurrence and metastasis. Even after… Continue Reading →

Aphids use sight to avoid deadly bacteria, could lead to pest control

Pea aphids — a serious agricultural pest — have the ability to see and avoid a common, aphid-killing bacteria on plant leaves, according to a new Cornell University study published in Current Biology. Pea aphids lack immune-response genes, making them… Continue Reading →

Value-Added Agriculture: Creating New Opportunities in an Era of Uncertainty

Value-added business investments help farmers expand their operations, create jobs, and enhance their communities. Photo Credit: USDA Long before the Trump trade war was propelling the agriculture economy into new realms of uncertainty, many producers were already struggling with persistently… Continue Reading →

Where are they? Cosmologists search Andromeda for signs of alien life

"Are we alone in the universe?" The question has fascinated, tantalized and even disconcerted humans for as long as we can remember. So far, it would seem that intelligent extraterrestrial life — at least as fits our narrow definition of… Continue Reading →

Ledumahadi mafube: South Africa’s new jurassic giant

A new species of a giant dinosaur has been found in South Africa's Free State Province. The plant-eating dinosaur, named Ledumahadi mafube, weighed 12 tonnes and stood about four metres high at the hips. Ledumahadi mafube was the largest land… Continue Reading →

Physical exercise improves the elimination of toxic proteins from muscles

A study published in Scientific Reports by researchers at the University of São Paulo (USP) in Brazil, in partnership with colleagues in the United States and Norway, shows that the lack of muscle stimulus results in a buildup of inadequately… Continue Reading →

Putting noise to work

Noise is often an undesirable phenomenon, for example a recorded conversation in a noisy room, astronomical observations with large background signals or in image processing. A research team from China, Spain, and Germany has demonstrated that noise can induce spatial… Continue Reading →

Beach sand ripples can be fingerprints for ancient weather conditions

When a coastal tide rolls out, it can reveal beautiful ripples in the temporarily exposed sand. These same undulating patterns can also be seen in ancient, petrified seabeds that have been exposed in various parts of the world and preserved… Continue Reading →

How swarms of nanomachines could improve the efficiency of any machine

All machines convert one form of energy into another form – for example a car engine turns the energy stored in fuel into motion energy. Those processes of energy conversion, described by the theory called thermodynamics, don't only take place… Continue Reading →

Research teams find widespread inflammation in the brains of fibromyalgia patients

A study by Massachusetts General Hospital (MGH) researchers — collaborating with a team at the Karolinska Institutet in Sweden — has documented for the first time widespread inflammation in the brains of patients with the poorly understood condition called fibromyalgia…. Continue Reading →

2018 Arctic summertime sea ice minimum extent tied for sixth lowest on record

Arctic sea ice likely reached its 2018 lowest extent on Sept. 19 and again on Sept. 23, according to NASA and the NASA-supported National Snow and Ice Data Center (NSIDC) at the University of Colorado Boulder. Analysis of satellite data… Continue Reading →

Ride-hailing increases vehicle miles traveled

Ride-hailing accounts for an 83 percent increase in the miles cars travel for ride-hailing passengers in Denver's metro area, according to a study published this week in the journal Transportation by researchers at the University of Colorado Denver. Lead author… Continue Reading →

Secretary Purdue Rings Bell for Agriculture

U.S. Secretary of Agriculture Sonny Perdue rang the closing bell at the New York Stock Exchange on Wednesday afternoon, along with agriculture industry representatives both on and off the podium. “The farmers, ranchers, foresters and agricultural producers across America contribute… Continue Reading →

Postnatal depression could be linked to fewer daylight hours during late pregnancy

Women in late pregnancy during darker months of the year may have a greater risk of developing postpartum depression once their babies are born. This is consistent with what is known about the relationship between exposure to natural light and… Continue Reading →

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